Research Question: (RQ95):
What is the diagnostic accuracy of multiple current and emerging Point-of-Care-Tests (POCTS) for active and past COVID-19 infection in the community setting?
Simon de Lusignan, Nuffield Dept. of Primary Care Health Sciences, University of Oxford
Research Question Narrative:
Point-of-care tests (POCTs) can be used in the community where there is no easy access to a specialist laboratory, in locations such as NHS general practices. POCTs provide quick results that allow people to get immediate advice about self-isolation and treatment, potentially blocking further spread of infection in the community. In-context evaluation of POCTs in the community is important as test accuracy can vary based on the prevalence of disease in the population tested. The severity of the COVID-19 disease in the community is much lower than in hospital patients.
RAPTOR-C19 will provide the community testbed to the COVID-19 National DiagnOstic Research and Evaluation Platform (CONDOR). CONDOR is the collaborative national platform for COVID-19 diagnostics research and evaluation. CONDOR will evaluate the analytical performance of in vitro diagnostics (IVDs) (molecular, antigen and antibody tests) via its laboratory network, and evaluate the in-context clinical performance (diagnostic and prognostic accuracy) of IVDs (self-tests, POCTs and laboratory platforms) in the network of community and secondary care settings. These include the community, emergency departments, acute ambulatory care and acute medicine units, critical care units and hospital at home services.
We are rapidly setting up to take tests for evaluation for DHSC as the community setting of the COVID-19 National DiagnOstic Research and Evaluation Platform CONDOR (recently UKRI/MRC funded). Would be good to discuss with you what might be possible regarding further connections.
SAGE Priority Area:
Direct Impact; Indirect Impact - Healthcare Pressures and socio-economic factors
Data Sourcing Requirements:
Participant data from eCRF, HER from ORCIDH and the RCGP Research Surveillance Centre (RSC) Network
-08/06/2020: RAPTOR has cleared REC. Of over 200 expressions of interest the study team has identified the practices to be included in the first wave of recruitment. The team is now working with the NIHR CRN to operationalise RAPTOR at these sites so that point-of-care tests identified by DHSC and triaged for primary care by CONDOR can be evaluated in context.
-25/05/2020: Expanding national RAPid community Test evaluation capacity fOR COVID-19 (RAPTOR-C19).
RAPTOR-C19 incorporates a series of prospective observational parallel diagnostic accuracy studies of COVID19 POCTS against PHE laboratory and linked electronic health records composite reference standards in patients with suspected current or past COVID-19 attending community settings such as NHS general practices enrolled with the RCGP-RSC and national COVID-19 testing centres. We are rapidly setting up to take tests for evaluation for DHSC as the community setting of the COVID-19 National DiagnOstic Research and Evaluation Platform CONDOR (recently UKRI/MRC funded).
Original content: https://web.www.healthdatagateway.org/project/556463473196918